Sequencing-based genotyping and association analysis of the MICA and MICB genes
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Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes.
OBJECTIVE The nonclassical major histocompatibility complex (MHC) class I chain-related molecules (MICs), encoded within the MHC, function in immunity. The transmembrane polymorphism in MICA (MICA-STR) has been reported to be associated with type 1 diabetes. In this study, we directly sequenced both of the highly polymorphic MIC genes (MICA and MICB) in order to establish whether they are assoc...
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تاریخ انتشار 2008